Top QB & RB Starts
Brock Purdy stands out as a strong start for Week 15. The 49ers have the slate’s second-highest implied total at 28.5 points against Tennessee, who allowed the third-most fantasy points to QBs over the last four weeks, including big games to Shedeur Sanders, Sam Darnold, and Trevor Lawrence.[2]
For running backs, Woody Marks and Devin Neal benefit from favorable setups. The 49ers' tone-setting offense provides reliable volume, cutting through playoff noise with trusted production.[2]
These picks leverage recent trends and defensive weaknesses, ideal for high-stakes lineups.[1]
WR & TE Start/Sit Picks
Isaiah Likely is a booming start at tight end. The Ravens TE has topped 12 PPR points in two straight games with six targets each, outproducing Mark Andrews since Week 11 on fewer routes against a historically favorable Cincinnati matchup.[2]
Michael Pittman is a clear sit despite his top-10 season ranking. Indianapolis faces Seattle, who allow the second-fewest points per game and rank sixth against WRs, with the Colts implied for just 14.5 points as big underdogs.[2]
Jakarta's WRs exploit the Jets post-Sauce Gardner, offering WR3 upside with top-15 potential.[2]
D/ST & Flex Advice
San Francisco's defense is a prime start against Tennessee, who rank second in fantasy PPG allowed to opponents, with high sack rates and giveaways. Dallas Cowboys D/ST also shines hosting Minnesota, the most generous to defenses lately.[4]
Sit the Rams defense versus Detroit, who allow the fewest fantasy PPG to units all season in a high-scoring dome affair.[4]
Flex spots favor heating players like Jauan Jennings in soft matchups, prioritizing upside over risk in playoffs.[2][5]